Klaus Rajewsky
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Modeling human diseases in mice
Conditional gene targeting is ideally suited for the modeling of human diseases in mice. The Rajewsky lab has produced numerous such mouse models, including models of various immunodeficiencies, Crohn's disease, and pulmonary fibrosis. Targeted mutagenesis of the NFkB signaling pathway has led to a mouse model of the genetic disease Incontinentia Pigmenti. Relating to the extensive work of the Rajewsky group on the origin of human lymphomas, in particular Hodgkin's disease (HD), they are also heavily involved in generating mouse models of human mature B cell lymphomas.
